REALTIONSHIP BETWEEN MENARCHE AND REPRODUCTIVE AGE WITH LIPID PROFILE IN PERIMEDOPAUSAL AND POSTMENOPAUSAL WOMEN
DOI:
https://doi.org/10.59417/nir.2019.15.93Keywords:
menopause, lipid status, menarcha.Abstract
Menopausal transition is a period characterized by psychic, somatic and changes in the reproductive capacity of a woman. It occurs as a result of quenching of the ovarian function, and refers to periods with different meanings: perimenopause, menopause and postmenopausal. The level of lipoprotein in girls and boys in puberty is similar. The gender difference in HDL cholesterol occurs during puberty and women have an average 10 mg / dL higher HDL cholesterol level than men throughout their lifetime. According to recent studies, it affects HDL cholesterol and reduced triglyceride levels, and a longer reproductive period is also associated with increased body weight, and unlike years of menstruation, it is characterized by a reduced level of HDL and all other cholesterol. The aim of the study was to determine the relationship between menarche and reproductive age with lipid and hormonal profiles in women in perimenopause and postmenopausal women. This prospective, comparative survey was carried out in the period from November 2009 to December 2010 and included a total of 150 respondents divided into three groups and a life span of 40–55 years. Based on the obtained regression coefficients and the corresponding P values, we can not conclude that there is a significant relationship between menarche and lipid profile in subjects in premenopausal, perimenopause and postmenopausal, and we can not confirm that there is a significant relationship between reproductive age and lipid profile. Lifetime is an important independent predictor for LDL and total cholesterol in women, but it is not as influential as a body constitution and lifestyle affect the level of HDL, LDL, and triglycerides in women.
References
Aloysio, D., Gambacciani, M., Meschia, M., Pansini, F. (2003) The effect of menopause on blood lipid and lipoprotein levels. Atherosclerosis 147 (1): 147–153. DOI: https://doi.org/10.1016/S0021-9150(99)00315-9
Berg, G., Mesh, V., Boero, L., Sayegh, F., Prada, M., Royer, M., Muzzio, ML., Schreier, L., Sisele, N., Benanacia, H. (2004) Lipid and lipoprotein profile in menopausal transition. Effects of hormones, age and fat distribution. Horm Metab Res 36 (4): 215–220. DOI: https://doi.org/10.1055/s-2004-814450
Bittner, V. (2005). Perspectives on Dyslipidemia and Coronary Heart Disease in Women J Am Coll Cardiol 46: 1628–1635. DOI: https://doi.org/10.1016/j.jacc.2005.05.089
Brooks, M. (2009). Adverse Lipid Changes Seen During Menopausal Transition. J Am College Cardiol. 54: 2366–2373 and 2374–2375. DOI: https://doi.org/10.1016/j.jacc.2009.10.009
Čaparević, Z., Kostić, N. (2007). The influence of age and the beginning of menopause on the lipid profil, LDL oxidation, and CRP in healthy women. Srpski arhiv za celokupno lekarstvo, 135 (5– 6): 280–285. DOI: https://doi.org/10.2298/SARH0706280C
Derby, CA., Crawford, SL., Pasternak, RC., Sowers, M., Sternfeld, B., Matthews, KA. (2009). Lipid Changes During the Menopause Transition in Relation to Age and Weight. The Study of Women’s Health Across the Nation. American Journal of Epidemiology 169 (11): 1352–1361. DOI: https://doi.org/10.1093/aje/kwp043
Hall, G., Collins, A., Csemiczky, G., Landgren, BM. (2002). Lipoproteins and BMI: a comparison between women during transition to menopause and regularly menstruating healthy women. Maturitas 41 (3): 177–185. DOI: https://doi.org/10.1016/S0378-5122(01)00258-4
Jensen, J., Nilas, L., Christiansen, C. (1990). Influence of menopause on serum lipids and lipoproteins. DOI: https://doi.org/10.1016/0378-5122(90)90012-U
Maturitas 12 (4): 321–331.
Kim, CJ., Kim, TH., Ryu, WS., Ryoo, UH. (2000). Influence of menopause on high density lipoprotein – cholesterol and lipids. J Korean Med Sci. 15 (4): 380–390. DOI: https://doi.org/10.3346/jkms.2000.15.4.380
Kojić-Damjanov, S., Đerić, M., Čabarkapa, V., Vučurević-Ristić, Lj. (2007). Značaj odreĎivanja nivoa apolipoproteina A-I i B u dijagnostici i proceni aterogenog rizika lipidskog porekla u hiperalfa – lipoproteinemiji, hipoholesterolemiji i hipo-HDL-holesterolemiji. J of Med Biochem. 26 (3): 206–214. DOI: https://doi.org/10.2478/v10011-007-0024-6
Matthews, KA., Wing, RR., Kuller, LH., Meilahn, EN., Plantinga, P. (1994). Influence of the perimenopause on cardiovascular risk factors and symptoms of middle-aged healthy women. Arch Intern Med.154 (20): 2349–2355. DOI: https://doi.org/10.1001/archinte.1994.00420200105011
Mešalić, L. (2005). Lipidni profil žena u menopauzi. Magistarski rad. Medicinski fakultet, Univerzitet u Tuzli: 34–58.
Prelević, G. (1996). „Menopauza”. U: Prelević, G. Klinička reproduktivna endokrinologija. Beograd: Nauka, 216–217.
Remsberg, KE., Demerath, EW., Schubert, CM., Chumlea, WC., Sun SS and Siervogel RM (2005) Early menarche and the Development of Cardiovascular Disease Risk Factors in Adolescent Girls: The Fels Longitudinal Study. J Clin Endocrinol Metab. 90 (5): 2718–2724. DOI: https://doi.org/10.1210/jc.2004-1991
Schubert, CM., Rogers, NL., Remsberg, KE., Sun SS, Chumlea WC, Demerath EW, Czerwinski SA, Towne B, Siervogel RM (2006) Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study. Int J Obes (Lond); 30(2): 251–260. DOI: https://doi.org/10.1038/sj.ijo.0803129
Šimunić, V. (2001). „Klimakterij, menopauza i postmenopauza“. U: Šimunić, V. i sar. Ginekologija. Zagreb: Naklada Ljevak, 368–387.
Torng PL, Su TC, Sung FC, Chien KL, Huang SC, Chow SN, Lee YT (2002) Effects of menopause on intraindividual changes in serum lipids, blood pressure, and body weight--the Chin-Shan Community Cardiovascular Cohort study. Atherosclerosis 161 (2): 409-15. DOI: https://doi.org/10.1016/S0021-9150(01)00644-X
Usoro, C.A.O., Adikwuru, C.C., Usoro, I.N. and Nsonwu, A.C. (2006). Lipid Profile of Postmenopausal Women in Calabar, Nigeria. Pakistan Journal of Nutrition 5 (1): 79–82. DOI: https://doi.org/10.3923/pjn.2006.79.82
Wiacek, M., Hagner, W., Zubrzycki, IZ. (2011). Measures of menopause driven differences in levels of blood lipids, follicle-stimulating hormone, and luteinizing hormone in women aged 35 to 60 years: National Health and Nutrition Examination Survey III and National Health and Nutrition Examination Survey 1999-2002 study. Menopause 18 (1): 60–66. DOI: https://doi.org/10.1097/gme.0b013e3181e7060b
Xin, X. (2008). Age at manarche, reproduktive years, menopause increase metabolic risk. Atherosclerosis 196: 590–597. DOI: https://doi.org/10.1016/j.atherosclerosis.2007.06.016
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