POVEZANOST MENARHE I DUŽINE REPRODUKTIVNE DOBI SA LIPIDNIM PROFILOM KOD ŽENA U PERIMENOPAUZI I POSTMENOPAUZI

Lejla Mešalić; Fejzo Begović

doi:10.59417/nir.2019.15.93

Autor(i)

Lejla Mešalić Sluţba za zdravstvenu zaštitu ţena i trudnica – JZNU, Dom zdravlja, Tuzla BiH
Fejzo Begović Nezavisni univerzitet Banja Luka, BiH

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https://doi.org/10.59417/nir.2019.15.93

Ključne riječi:

menopauza, lipidni status, menarha.

Sažetak

Menopauzalna tranzicija je period kojeg karakterišu psihičke, somatske i promjene u reproduktivnoj sposobnosti ţene. Nastaje kao posljedica gašenja ovarijalne funkcije, a odnosi se na periode sa razlicitim značenjem: perimenopauza, menopauza i postmenopauza. Nivo lipoproteina kod djevojčica i dječaka u pubertetu je sličan. Razlika meĎu polovima u HDL holesterolu se javlja za vrijeme puberteta i ţene imaju prosječno 10 mg/dl veći nivo HDL holesterola za razliku od muškaraca kroz svoj ţivotni vijek. Prema novijim studijama ona utiče na povećanje HDL holesterola i smanjen nivo triglicerida, a duţi reproduktivni period se takoĎe povezuje sa povećanom tjelesnom teţinom, i za razliku od godina pojavljivanja menarhe, karakterišu ga smanjen nivo HDL i svih drugih holesterola. Cilj istraţivanja je bio utvrditi povezanost menarhe i duţine reproduktivne dobi sa lipidnim i hormonskim profilom kod ţena u perimenopauzi i postmenopauzi. Ovo prospektivno, komparativno istraţivanje obavljeno je u periodu novembar 2009–decembar 2010. godine, a obuhvatilo je ukupno 150 ispitanica koje su podijeljene u tri grupe a ţivotne dobi od 40–55 godina. Na osnovu dobijenih regresijskih koeficijenata i pripadajućih P vrijednosti ne moţemo zaključiti da postoji značajan odnos izmeĎu menarhe i lipidnog profila kod ispitanica u premenopauzi, perimenopauzi i postmenopauzi i ne moţemo potvrditi da postoji značajan odnos izmeĎu reproduktivne dobi i lipidnog profila. Ţivotna dob je vaţan nezavisni prediktor za LDL i ukupni holesterol kod ţena, ali nije toliko uticajna kao što konstitucija tijela i ţivotni stil utiču na nivo HDL, LDL i trigliceride kod ţena.

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